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Clinical studies targeting HMGB1 in depression.
| S.N. | Type of study | Treatment | Observations | limitation | References | |
|---|---|---|---|---|---|---|
| Experimental | Control | |||||
| 1 | Randomized, double-blind, placebo-controlled clinical trial | SSRI + GL | SSRI + PBO | The SSRI + GL group had more relief of depressive symptoms than the SSRI+PBO group | The sample size of this study was not large enough and the follow-up time was relatively short | (116) |
