Table 2.
Tranexamic acid in patients with hip fracture.28
| Author (year) | RCT | Intervention: doses TXA | N patients (TXA vs Control) | Blood loss mL (SD mL) (TXA vs Control) | % Transfusion (TXA vs Control) | Adverse effects | Jadad7 |
|---|---|---|---|---|---|---|---|
| Sadeghi | Yes | 15.ámg.kg-1 IV bolus | 32 | 960 (284) | 37 | No reported | 3 |
| 2007 | 35 | 1484 (374) | 57 | ||||
| Zufferey | Yes | 15.ámg.kg-1 preoperatively IV bolus and repeat at 3.áhours later | 57 | 975 (741)a | 42 | 16% vascular adverse effects at 6 weeks in TXA group and 6% in placebo group | 3 |
| 2010 | 53 | 1178 (912)a | 60 | ||||
| Vijay | Yes | 500.ámg preoperatively IV bolus.á+.áinfusion 1.ámg.kg-1.h-1 during surgery until end | 45 | 39b (10) | 16 | No reported | 4 |
| 2013 | 45 | 91b (17,6) | 40 | ||||
| Emara | Yes | - 1- 10.ámg.kg-1 bolus preop.á+.ácontinuous infusion of 500.ámg in 250.ámL of SS with an infusion of 80.ámL.h-1 until the end of surgery. | IV 20 | 640 (25) | 5 | 6 patients in TXA IV group (five cases of DVT and one case of stroke) versus 1 patient with DVT in the control group and no case in the topic TXA group | 3 |
| 2014 | - 1.5.ág TXA in 100.ámL SS | Topic 20 | 625 (35) | 5 | |||
| - SS topic | Control 20 | 1100 (30) | 35 | ||||
| Lee | NO | 1.ág IV bolus preoperatively | 84 | No reported | 6 | There were no differences in mortality between both groups at 30 and 90 days. | 3 |
| 2015 | 187 | 19 | |||||
| Kang | Yes | 3.ág in 100.ámL SS topic through surgical deep drainage | (c) | 600 (53) | 45 | No reported | 3 |
| 2016 | 40 | 737 (62) | 60 | ||||
| 40 | |||||||
| Tengberg | Yes | 1.ág IV bolus preop.á+.áIV infusion 3.ág in 24.áh | 33 | 1526.6 (1012.7) | 81.8 | 90-day mortality was 27,2% in the TXA group compared to 10,2% (n.á=.á4) in placebo group | 4 |
| 2016 | 39 | 2100,4 (1152,6) | 84.6 | ||||
| Baruah | NO | 15.ámg.kg-1 bolus IV 15.áminutes before surgery | 30 | 408,97 (106,35) | 90 | No reported | |
| 2016 | 30 | 676,67 (87,88) | 100 | ||||
| Watts | Yes | 2 doses of 15.ámg.kg-1 in 100.ámL SS IV prior to the incision and another at the end of the surgery | 69 | 902 | 17 | There were no differences in mortality between both groups at 30 and 90 days | 4 |
| 2017 | 69 | 1205 | 26 |
RCT, Randomized control trial; SS, saline serum; SD, standard deviation; TXA, Tranexamic acid; IV, intravenous.
a
Median (Interquartile Range).
b
Deep drainage volumen.
c
Only patients with hip fracture.