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MK-2206 inhibited phosphorylation of AKT downstream targets in GPC1 overexpressed cells. OE19 cells were transfected with GPC1 overexpression plasmid or EV and treated with 1 µM of MK-2206 for 24 h. Western blot was performed and probed for active p-AKT, p-GSK3-β and p-β-catenin. MK2206 attenuated increased levels of p-AKT, p-GSK3-β, and p-β-catenin induced by LV-GPC1. LV-GPC1, overexpressing GPC1 lentivirus; GPC1, glypican 1.
