Table 1.
Distribution of genotypic frequencies in PE− vs. PE+ COVID-19 patients
| Polymorphism | PE− | PE+ | P |
|---|---|---|---|
| FV R506Q, n (%) | 0.43 | ||
| G/G (homozygous wild type) | 45 (95.7) | 42 (91.3) | |
| G/A (heterozygous) | 2 (4.3) | 4 (8.7) | |
| AA (homozygous mutant) | 0 (0.0) | 0 (0.0) | |
| FV H1299R, n (%) | 0.66 | ||
| A/A (homozygous wild type) | 41 (87.2) | 38 (82.6) | |
| A/G (heterozygous) | 6 (12.8) | 7 (15.2) | |
| G/G (homozygous mutant) | 0 (0.0) | 1 (2.2) | |
| FII, n (%) | 0.20 | ||
| G/G (homozygous wild type) | 46 (97.9) | 42 (91.3) | |
| G/A (heterozygous) | 1 (2.1) | 4 (8.7) | |
| A/A (homozygous mutant) | 0 (0.0) | 0 (0.0) | |
| MTHFR C677T, n (%) | 0.77 | ||
| C/C (homozygous wild type) | 15 (31.9) | 15 (32.6) | |
| C/T (heterozygous) | 20 (42.6) | 22 (47.8) | |
| T/T (homozygous mutant) | 12 (25.5) | 9 (19.6) | |
| MTHFR A1298C, n (%) | 0.06 | ||
| A/A (homozygous wild type) | 22 (46.8) | 15 (32.6) | |
| A/C (heterozygous) | 24 (51.1) | 24 (52.2) | |
| C/C (homozygous mutant) | 1 (2.1) | 7 (15.2) | |
| CBS 844ins68, n (%) | 0.03 | ||
| D/D (homozygous wild type) | 38 (80.9) | 44 (95.7) | |
| I/D (heterozygous) | 9 (19.1) | 2 (4.3) | |
| I/I (homozygous mutant) | 0 (0.0) | 0 (0.0) | |
| PAI-1-675 (4G/5G), n (%) | 0.67 | ||
| 5G5G (homozygous wild type) | 10 (21.3) | 10 (21.7) | |
| 4G5G (heterozygous) | 30 (63.8) | 26 (56.5) | |
| 4G4G (homozygous mutant) | 7 (14.9) | 10 (21.7) | |
| HPA1 T1565C GP IIIa, n (%) | 1.00 | ||
| T/T (homozygous wild type) | 29 (61.7) | 30 (65.2) | |
| T/C (heterozygous) | 16 (34.0) | 15 (32.6) | |
| C/C (heterozygous) | 2 (4.3) | 1 (2.2) | |
| ACE I/D, n (%) | 0.04 | ||
| I/I (homozygous wild type) | 5 (10.6) | 8 (17.4) | |
| I/D (heterozygous) | 23 (48.9) | 11 (23.9) | |
| D/D (homozygous mutant) | 19 (40.4) | 27 (58.7) | |
| APOE T112C, n (%) | 0.36 | ||
| T/T (homozygous wild type) | 43 (93.6) | 38 (82.6) | |
| T/C (heterozygous) | 3 (6.4) | 7 (15.2) | |
| C/C (homozygous mutant) | 1 (2.1) | 1 (2.2) | |
| APOE T158C, n (%) | 0.02 | ||
| T/T (homozygous wild type) | 0 (0.0) | 1 (2.2) | |
| T/C (heterozygous) | 15 (31.9) | 5 (10.9) | |
| C/C (homozygous mutant) | 32 (68.1) | 40 (87.0) | |
| AGT T9543C, n (%) | 0.82 | ||
| T/T (homozygous wild type) | 12 (25.5) | 10 (21.7) | |
| T/C (heterozygous) | 25 (53.2) | 23 (50.0) | |
| C/C (homozygous mutant) | 10 (21.3) | 13 (28.3) | |
| AGTR-1 A1166C, n (%) | 0.63 | ||
| A/A (homozygous wild type) | 28 (59.6) | 26 (56.5) | |
| A/C (heterozygous) | 14 (29.8) | 17 (37.0) | |
| C/C (homozygous mutant) | 5 (10.6) | 3 (6.5) | |
| FBG -455, n (%) | 0.14 | ||
| G/G (homozygous wild type) | 21 (44.7) | 30 (65.2) | |
| G/A (heterozygous) | 22 (46.8) | 13 (28.3) | |
| A/A (homozygous mutant) | 4 (8.5) | 3 (6.5) | |
| F XIII, n (%) | 0.12 | ||
| G/G (homozygous wild type) | 29 (61.7) | 34 (73.9) | |
| G/T (heterozygous) | 14 (29.8) | 12 (26.1) | |
| T/T (homozygous mutant) | 4 (8.5) | 0 (0.0) |
Statistically significant p-values (p < 0.05) are highlighted in bold