Table 4.
Macroscopy evaluation of lesions found on mice experimentally infect by C. pseudotuberculosis. Organs were obtained after necropsy and were then analyzed by veterinarian pathologists
| Organs | Lesions | |||
|---|---|---|---|---|
| G1 | G2 | G3 | G4 | |
| Kidneys | Multifocal granulomatous nephritis (n = 4) | Multifocal granulomatous nephritis (n = 5) | Multifocal granulomatous nephritis (n = 2) | Multifocal granulomatous nephritis (n = 5) |
| Liver | Mild degeneration and multifocal hepatitis/necrosis; focal granulomatous hepatitis (n = 5) | Mild degeneration and multifocal hepatitis/necrosis; focal granulomatous hepatitis (n = 5) | Mild degeneration and multifocal hepatitis/necrosis; focal granulomatous hepatitis (n = 2) | Mild degeneration and multifocal hepatitis/necrosis; focal granulomatous hepatitis (n = 5) |
| Lungs | Focal granulomatous pneumonia (n = 1) | – | – | – |
| Spleen | – | Focal granulomatous splenitis (n = 2) | – | – |
| Heart | – | – | Focal granulomatous myocarditis (n = 1) | Focal granulomatous myocarditis (n = 1) |
| Systemic | Congestion and hemorrhagic lesions (n = 3) | Congestion and hemorrhagic lesions (n = 4) | – | Congestion and hemorrhagic lesions (n = 2) |
| Total of lesions | 13 | 16 | 5 | 13 |