Table 2.
Comparison of consumption and costs of antibiotics between periods
| DRD, mean/month (SD) | Preinterventiona | Interventionb | % reduction | p value |
|---|---|---|---|---|
| Total antibiotics | 63.2 (15.1) | 22.8 (13.7) | 63.8 | < 0.001 |
| Penicillins (amoxicillin, cloxacillin) | 4.6 (3.4) | 3.3 (2.2) | 28.3 | 0.282 |
| Amoxicillin-clavulanic acid | 20.8 (5.0) | 4.3 (3.3) | 79.3 | < 0.001 |
| Cephalosporins | 9.6 (6.9) | 5.8 (4.9) | 39.6 | 0.052 |
| Fluoroquinolones | 18.8 (9.5) | 3.5 (2.4) | 81.4 | < 0.001 |
| Fosfomycin calcium | 1.4 (0.9) | 0.6 (1.0) | 57.1 | 0.002 |
| Fosfomycin-tromethamine | 1.7 (1.0) | 1.1 (0.6) | 35.3 | 0.058 |
| Macrolides | 2.8 (2.7) | 2.3 (7.0) | 17.9 | 0.013 |
| Sulfonamides | 1.6 (1.3) | 0.9 (0.6) | 43.8 | 0.070 |
| Other antibiotics | 1.9 (1.7) | 1 (1.6) | 47.4 | 0.055 |
| Costs of antibiotics (euros), median/trimester (IQR) | 818.9 (688.7–987.4) | 438.0 (237.7–720.6) | 46.5 | 0.013 |
DRD defined daily doses (DDD) per 1000 residents per day, IQR interquartile range, SD standard deviation
aJanuary 1, 2018–June 30, 2019
bJuly 1, 2019 to December 31, 2020