Table 2.
Top upregulated and downregulated NK cell Gene Ontology (GO) values in JDM patients.
| Accession | Description | Number of Genes | logFC | P value |
|---|---|---|---|---|
| GO:1903047 | Mitotic cell cycle process | 712 | 7.351245 | 1.66E-13 |
| GO:0000278 | Mitotic cell cycle | 818 | 7.317412 | 1.99E-13 |
| GO:0022402 | Cell cycle process | 1065 | 6.939867 | 2.60E-12 |
| GO:0007049 | Cell cycle | 1425 | 6.906268 | 3.06E-12 |
| GO:0006950 | Response to stress | 2661 | 6.84279 | 4.32E-12 |
| GO:0051276 | Chromosome organization | 991 | 6.797868 | 7.00E-12 |
| GO:0006952 | Defense response | 1004 | 6.662913 | 1.75E-11 |
| GO:0002376 | Immune system process | 2034 | 6.383504 | 9.63E-11 |
| GO:0007059 | Chromosome segregation | 265 | 6.456295 | 1.26E-10 |
| GO:0044772 | Mitotic cell cycle phase transition | 478 | 6.18707 | 4.57E-10 |
| GO:0043207 | Response to external biotic stimulus | 574 | 6.143942 | 5.66E-10 |
| GO:0051707 | Response to other organism | 574 | 6.143942 | 5.66E-10 |
| GO:0000819 | Sister chromatid segregation | 166 | 6.275086 | 5.76E-10 |
| GO:0006955 | Immune response | 1420 | 6.034535 | 9.02E-10 |
| GO:0044770 | Cell cycle phase transition | 507 | 6.060856 | 9.58E-10 |
| GO:0009607 | Response to biotic stimulus | 601 | 6.048269 | 9.94E-10 |
| GO:0045087 | Innate immune response | 619 | 6.044385 | 1.01E-09 |
| GO:0009605 | Response to external stimulus | 1348 | 5.91724 | 1.85E-09 |
| GO:0098813 | Nuclear chromosome segregation | 212 | 6.021872 | 1.95E-09 |
| GO:0006260 | DNA replication | 243 | 5.881377 | 3.80E-09 |
| GO:0006259 | DNA metabolic process | 833 | 5.762369 | 4.94E-09 |
| GO:0098542 | Defense response to other organism | 299 | 5.814659 | 5.30E-09 |
| GO:0048285 | Organelle fission | 337 | 5.766276 | 6.33E-09 |
| GO:0051301 | Cell division | 479 | 5.727649 | 6.89E-09 |
| GO:0000280 | Nuclear division | 305 | 5.709448 | 9.05E-09 |
| GO:0006613 | Co-translational protein targeting to membrane | 97 | -4.02271 | 4.54E-05 |
| GO:0006614 | SRP-dependent co-translational protein targeting to membrane | 93 | -4.02124 | 4.64E-05 |
| GO:0045047 | Protein targeting to ER | 106 | -3.87484 | 7.71E-05 |
| GO:0072599 | Establishment of protein localization to endoplasmic reticulum | 109 | -3.74763 | 0.000122 |
List of the top 25 significantly upregulated and the 4 significantly downregulated Biological Process GO categories in new-onset JDM NK cells compared to healthy pediatric controls.