Figure 1.

Abnormal PC1/3 phenotypes in beta cells of type 1 diabetes donors. Photomicrographs illustrate T1D islets costained for PC1/3 (green) and insulin (blue). Photomicrographs A to C are representative of all islets of each donor. While expression of PC1/3 in beta cells of islet of control (A) is heterogeneous, the level of the convertase in all beta cells of type 1 diabetes donors is homogeneous and either very high (B) or very low (C). Donor identification is indicated. Cells with green fluorescence remain to be identified. Bar: 12 um. Abbreviations: PC1/3, proprotein convertase 1/3; T1D, type 1 diabetes.