Figure 2.
Different pancreatic regions contain either normal or abnormal islets. Islets were triple-labeled for PC1/3 (A, E), proinsulin (B, F), and insulin (C, G); D, H illustrate the overlap of the three labels. Photomicrographs of pancreas of donor # 6397 document the presence of normal islets in the tail region (A–D) and PC1/3high islets in the body region (E–H) of the pancreas. Note that the expression of PC1/3 is heterogeneous in A and homogeneously high in E. Bar: 20 um. Abbreviation: PC1/3, proprotein convertase 1/3.