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Coexistence of normal and abnormal islets in the same pancreatic region. Photomicrographs of pancreatic islets of donor #6540 illustrate islets triple-labeled for PC1/3 (A, E), proinsulin (B, F), insulin (C, G). D and H show the overlap of the three markers. Note that PC1/3 expression is heterogeneous in A and homogeneously low in E. Bar: 15 um. Abbreviation: PC1/3, proprotein convertase 1/3.
