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. 2022 Nov 5;70(10):695–706. doi: 10.1369/00221554221138368

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Figure 4. — Fluorescent intensity and cellular allocation of proinsulin and insulin. Photomicrographs show sections of pancreas immunostained for ProIN (red), PC1/3 (green), and IN (blue). Figures illustrate beta cells with similar ProIN levels but different localization of the prohormone (A, donor #6450; B donor #6429); similar ProIN localization in donors with different number of autoantibodies (B, donor #6429; G, donor #6123); different PC1/3 phenotype but similar ProIN localization (C, donor #6505 and G, donor #6123); high ProIN immunostaining but very low IN and PC1/3 (H illustrates staining for ProIN and IN, I illustrates staining for PC1/3 and insulin, donor #6505); low ProIN and PC1/3 (E illustrates staining for PC1/3 and insulin and F shows immunostaining for ProIN and insulin, donor #6424). (D) Islet of T1D donor stained for insulin, proinsulin and PC1/3. Note that cells express only the proconvertase. Bar: 15 um. Abbreviation: PC1/3, proprotein convertase 1/3.