Table 1.
Donors Characteristics: Autoantibodies, Sex, age and marker expression levels of the Donors.
| GAD | IA2 | mIAA | ZnT8 | Age/sex | PR | ProIN | PC1/3 | IN | |
|---|---|---|---|---|---|---|---|---|---|
| Control | 22.1 ± 1.3 | 17.1 ± 0.6 | 38.4 ± 2 | ||||||
| 6424 | + | – | + | – | 17.6 years, M | PB | 11.8 ± 0.3* | 11.7 ± 0.6* | 27.8 ± 0.8** |
| PT | 9.6 ± 1.0** | 8.5 ± 0.7** | 26.0 ± 1.7** | ||||||
| 6505 | + | – | + | – | 20.5 years, F | PB | 30.2 ± 1.8* | 9.5 ± 0.6** | 34.4 ± 0.3 |
| PT | 16.5 ± 1.2* | 11.9 ± 1.3* | 38.3 ± 2 | ||||||
| 6314 | + | – | – | – | 21 years, M | PB | 17.8 ± 1.0 | 11.8 ± 0.8* | 34.0 ± 1.3 |
| PT | 18.1 ± 0.9 | 26.7 ± 0.9** | 38.1 ± 1.8 | ||||||
| 6450 | + | – | – | – | 20.5 years, F | PH | 14.6 ± 0.8** | 5.54 ± 0.5** | 36.6 ± 2.2 |
| PB | 15.0 ± 1.0** | 12.8 ± 1.2* | 32.0 ± 2.0 | ||||||
| 6517 | + | – | – | + | 22.1 years, M | PB | 21.3 ± 1.4 | 11.7 ± 0.6** | 33.4 ± 1.2 |
| PT | 19.3 ± 1.3 | 13.3 ± 1.0** | 39.3 ± 2.0 | ||||||
| 6123 | + | – | – | – | 23.2 years, F | PB | 23.8 ± 1.1 | 27.6 ± 1.0** | 44.2 ± 1.4** |
| PT | 21.3 ± 0.3 | 29.2 ± 1.0 | 39.6 ± 1.4 | ||||||
| 6397 | + | – | – | – | 21.1 years, F | PB | 13.3 ± 0.9** | 8.9 ± 1.8** | 29.2 ± 1.9** |
| PT | 16.5 ± 0.7** | 14.3 ± 0.6** | 29.5 ± 0.9** | ||||||
| 6429 | + | – | + | – | 22.1 years, M | PB | 15.1 ± 1.0** | 18.1 ± 1.8 | 39.0 ± 1.7 |
| PT | 14.9 ± 1.0** | 20.1 ± 1.4 | 38.5 ± 2.0 | ||||||
| 6520 | + | + | – | + | 21.6 years, M | PB | 12.6 ± 2.3** | 7.9 ± 0.7** | 43.8 ± 2.3 |
| PT. | 3.5 ± 1.5** | 28.9 ± 1.8** | 44.2 ± 3.1 | ||||||
| 6362 | + | – | – | – | 24.9 years, M | PB | 8.7 ± 1.0**. | 29.6 ± 2.4** | 45.2 ± 2.0 |
| PT | 2.4 ± 0.8**. | 15.8 ± 1.6* | 43.0 ± 2.2 | ||||||
| 6325 | + | + | + | – | 20 years, F | PB+ | 11.1 ± 0.72** | 24.0 ± 1.0* | 36.3 ± 3.8 |
| PT | |||||||||
| 5000 | + | – | + | – | 18.7 years, F | PB+ | 12.2 ± 1.7** | 9.8 ± 0.56** | 25.3 ± 3.3 |
| PT |
Fluorescence intensity/islet area of each functional marker. Two regions of the pancreas per donor and 10 to 25 islets per region of pancreas were evaluated. Italics: type 1 diabetic donors. In some of these donors, values from both pancreatic regions are combined. *X = p<0.05;**X = p<0.005
Abbreviations: IA2, tyrosine phosphatase-like insulinoma antigen; GAD65, glutamic acid decarboxylase-65; ZnT8, zinc transporter protein 8; micro mIAA, insulin; PC1/3, proprotein convertase 1/3; PR, pancreas region; ProIN, proinsulin; IN, insulin; PT, pancreas tail; PB, pancreas body; PH, pancreas head.