Table 2.

Classification of Donors According to Their PC1/3 Phenotype.

		R < 1	R > 1
6424	PB	0.68
	PT	0.47
6505	PB	0.5
	PT	0.7
6314	PB	0.7
	PT		1.5
6450	PH	0.4
	PB	0.7
6517	PB	0.68
	PT	0.76
6123	PB		1.7
	PT		1.5
6397	PB		1.1
	PT	0.8
6429	PB		1.8
	PT		1.1
6520	PB + PT	0.46
6362	PB + PT		1.7
6325	PB + PT		1.4
5000	PB + PT	0.5

The table illustrates the ratio (R) of the mean fluorescent intensity of PC1/3 per islet area in all islets of each donor over that of control. The same value for control islets was used for all calculations. Note that islets in different regions of the pancreas of autoantibody positive donors are populated by either PC1/3^high or PC1/3^low beta cells. Islets with PC1/3^high and PC1/3^low expression do not coexist in the same pancreatic region. At least 15 islets were evaluated for each pancreatic region per donor. Values close to that of control are due to the coexistence of normal and abnormal islets in the same section. Histogram illustrates the values of Table 2. Black lines: autoantibody positive donors; gray lines: type 1 diabetic donors. Note the presence of two abnormal groups according to their PC1/3 phenotype.

Abbreviations: PC1/3, proprotein convertase 1/3; PB, pancreas body; PT, pancreas tail; PH, pancreas head.