Table 3.
Classification of Donors According to Their Proinsulin (ProIN) and Insulin (IN) Phenotypes.
| Ratio ProIN | Ratio IN | |||
|---|---|---|---|---|
| <1 | >1 | |||
| 6424 | PB | 0.5 | 0.71 | |
| PT | 0.4 | 0.68 | ||
| 6505 | PB | 1.4 | 0.89 | |
| PT | 0.75 | 1.0 | ||
| 6314 | PB | 0.8 | 0.89 | |
| PT | 0.8 | 1.0 | ||
| 6450 | PH | 0.7 | 0.94 | |
| PB | 0.7 | 0.94 | ||
| 6517 | PB | 0.9 | 0.84 | |
| PT | 0.8 | 0.89 | ||
| 6123 | PB | 0.9 | 1.0 | |
| PT | 1.0 | 1.1 | ||
| 6397 | PB | 0.6 | 1.02 | |
| PT | 0.75 | 0.76 | ||
| 6429 | PB | 0.7 | 0.76 | |
| PT | 0.9 | 1.0 | ||
| 6520 | PB + PT | 0.5 | 1.0 | |
| 6362 | PB + PT | 0.1 | 1.1 | |
| 6325 | PB + PT | 0.1 | 0.9 | |
| 5000 | PB + PT | 0.5 | 0.7 | |
The table illustrates the ratio (R) of the mean fluorescent intensity per islet area of ProIN and IN in islets of each donor over that of control. The same value for control islets was used for all calculations. Note that different pancreatic regions of each donor have similar ProIN phenotype, except for donor #6505. Levels of proinsulin in pancreas of type 1 diabetes donors (italics) are similar or lower than that of autoantibody positive cohort.
Abbreviations: IN, insulin; ProIN, proinsulin; PB, pancreas body; PT, pancreas tail; PH, pancreas head.