. 2022 Sep 28;12(11):e2753. doi: 10.1002/brb3.2753

TABLE 3.

Association of interleukin SNPs with internalizing behaviors

		Internalizing problems					Anxiety					Depression
		Cases		Controls		Combined	Cases		Controls		Combined	Cases		Controls		Combined
Gene	SNP	𝛽_CAS	p_CAS	𝛽_CON	p_CON	p_META	𝛽_CAS	p_CAS	𝛽_CON	p_CON	p_META	𝛽_CAS	p_CAS	𝛽_CON	p_CON	p_META
IL1B	rs4849127	0.54	0.78	1.05	0.65	0.61	–0.51	0.81	4.24	0.06	0.90	–3.85	0.11	3.18	0.02	0.56
	rs16944	–0.19	0.84	0.60	0.54	0.77	–1.46	0.22	1.07	0.28	0.94	–0.45	0.71	0.61	0.31	0.64
	rs1143634	–0.11	0.92	0.16	0.89	0.98	0.44	0.75	1.85	0.11	0.17	–1.74	0.22	0.39	0.58	0.65
	rs1143643	0.36	0.70	–0.45	0.66	0.98	–0.17	0.88	–1.00	0.33	0.42	1.49	0.22	–0.76	0.22	0.98
IL2	rs2069762	–0.85	0.40	1.33	0.24	0.83	0.05	0.97	1.14	0.31	0.45	0.002	0.99	0.85	0.23	0.39
	rs2069778	–0.52	0.69	–2.23	0.12	0.17	0.88	0.60	–0.68	0.63	0.99	1.17	0.49	–0.57	0.51	0.99
	rs2069772	2.56	0.01	–0.90	0.45	0.21	0.32	0.81	–0.09	0.94	0.91	0.80	0.54	–0.36	0.62	0.94
IL6	rs2069827	1.01	0.53	–0.63	0.75	0.82	–3.66	0.07	–4.09	0.04	0.006	‐4.98	0.01	‐2.80	0.02	7.15×10⁻⁴
	rs2069837	–0.07	0.97	–0.57	0.76	0.81	–0.56	0.82	0.60	0.75	0.94	2.70	0.34	0.35	0.76	0.38
	rs2066992	1.24	0.49	4.19	0.04	0.05	1.77	0.43	4.28	0.03	0.04	2.98	0.16	2.40	0.05	0.02
	rs2069840	0.49	0.61	–0.72	0.52	0.93	1.35	0.26	–0.56	0.61	0.67	1.11	0.35	0.80	0.24	0.13
	rs2069861	–1.43	0.29	–0.19	0.90	0.40	–0.66	0.71	1.54	0.32	0.65	–2.59	0.14	0.26	0.79	0.40
	rs10242595	0.38	0.70	1.85	0.08	0.13	1.52	0.22	0.67	0.53	0.19	2.09	0.10	0.17	0.79	0.18

Association between SNPs and symptom severity was tested by linear regression with adjustment for age and gender as covariates, using an additive genotypic model; p‐values shown are not corrected for multiple testing, p_cor = 13*p‐value; 𝛽_CAS, effect size in cases; 𝛽_CON, effect size in controls; p_CAS, p‐value in cases; p _CON, p‐value in controls; p_META, p‐value in inverse variance‐weighted fixed effects meta‐analysis of effect in cases and controls.