TABLE 4.
Gene–environment interactions between interleukin SNPs and traumatic life experiences
| Gene | SNP | 𝛽 | p |
|---|---|---|---|
| IL1B | rs4849127 | 9.56 | 0.36 |
| rs16944 | –4.65 | 0.32 | |
| rs1143634 | –1.30 | 0.82 | |
| rs1143643 | 13.94 | 4.62×10−3 | |
| IL2 | rs2069762 | –0.80 | 0.88 |
| rs2069778 | 18.24 | 9.23×10−3 | |
| rs2069772 | 4.95 | 0.47 | |
| IL6 | rs2069827 | –13.3 | 0.07 |
| rs2069837 | –22.96 | 0.11 | |
| rs2066992 | 14.73 | 0.06 | |
| rs2069840 | –7.80 | 0.16 | |
| rs2069861 | –1.55 | 0.79 | |
| rs10242595 | –0.03 | 0.99 |
Note: Statistical interaction between each SNP and severe childhood adversity for depressive symptoms was tested by linear regression using a SNP*adversity interaction term with adjustment for main effects of SNP genotype and adversity as well as covariates age and gender; p‐values shown are not corrected for multiple testing, p cor = 13*p‐value.