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. 2022 Sep 16;28(22):4957–4967. doi: 10.1158/1078-0432.CCR-22-0275

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 3. Correlation of immune-related genes and immune cell estimates in CXCR4high and CXCR4low PDACs. A, High CXCR4 mRNA expression (green; Q4) is linked to an increase of several immune-related genes using whole transcriptomic analyses (all, P < 0.05). B, QuanTiseq analysis suggests an increase of immune cell infiltration in CXCR4high (Q4; green) compared with CXCR4low (Q1; blue) PDACs. C, CXCR4 mRNA expression is independent of MSI-H/dMMR and TMB. PD-L1 IHC expression shows a decrease from Q1 to Q4. **, P < 0.001; *, P < 0.01. — Correlation of immune-related genes and immune cell estimates in CXCR4^high and CXCR4^low PDACs. A, High CXCR4 mRNA expression (green; Q4) is linked to an increase of several immune-related genes using whole transcriptomic analyses (all, P < 0.05). B, QuanTiseq analysis suggests an increase of immune cell infiltration in CXCR4^high (Q4; green) compared with CXCR4^low (Q1; blue) PDACs. C,CXCR4 mRNA expression is independent of MSI-H/dMMR and TMB. PD-L1 IHC expression shows a decrease from Q1 to Q4. **, P < 0.001; *, P < 0.01.