Table 5.
Model coefficients for the best-fitting GAMMs of the right fronto-basal-ganglia circuit.
| Right IFG-preSMA (logFC) | |||
| Parametric coefficients | Est. (SE) | t | pFDR |
| Intercept | 0.008 (0.011) | 0.710 | 0.618 |
| SES_c | 0.0003 (0.0002) | 1.268 | 0.327 |
| FWD_c | -0.002 (0.010) | -0.23 | 0.848 |
| eTIV_c | 0.002 (0.0005) | 3.992 | 0.001 |
| OFscanner | -0.010 (0.007) | -1.400 | 0.270 |
| Smooth terms | edf (Ref.df) | F | pFDR |
| s(age_c) | 1.000 (1.000) | 16.489 | < 0.001 |
| s(SID) | 68.805 (71.000) | 64.894 | < 0.001 |
| Right preSMA-STN (logFC) | |||
| Parametric coefficients | Est. (SE) | t | pFDR |
| Intercept | 0.002 (0.008) | 0.234 | 0.848 |
| SES_c | 0.0002 (0.0001) | 1.315 | 0.304 |
| FWD_c | -0.003 (0.009) | -0.376 | 0.779 |
| eTIV_c | 0.002 (0.0003) | 8.120 | < 0.001 |
| OFscanner | -0.020 (0.006) | -3.230 | 0.007 |
| Smooth terms | edf (Ref.df) | F | pFDR |
| s(age_c) | 1.000 (1.000) | 26.269 | < 0.001 |
| s(SID) | 67.361 (71.000) | 26.981 | < 0.001 |
Note: Right IFG-preSMA (logFC): Log-transformed fiber cross-section of the right inferior frontal-gyrus to presupplementary motor area connection; Right preSMA-STN (logFC): Log-transformed fiber cross-section of the right presupplementary motor area to subthalamic nucleus connection; Est.: Estimated regression parameter; SE: Standard error; edf: Estimated degrees of freedom; Ref.df: Reference degrees of freedom; pFDR: False Discovery Rate corrected p value; s(age_c): Smoothed mean-centred age; SES_c: Mean-centred SES; s(SID): Subject ID entered as a random effect; FWD_c: Mean-centred FWD; eTIV_c: Mean-centred eTIV; OFscanner: Ordered factor of scanner type.