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Schematic representation of the retroviral construct that carries both the p40 and p35 genes and the neomycin resistance gene selectable marker. The p40 and p35 cDNAs were linked by a (Gly4Ser)3 polylinker and were regulated by the long terminal repeat (LTR) promoter. This plasmid vector, designated pLXSN/mIL-12, was capable of coordinately expressing the p40, p35, and neomycin resistance genes. CMV, cytomegalovirus; SV40, simian virus 40.
