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Structures of KCNQ1-CaM in different ligand-bound states. (A) The cryo-EM maps of KCNQ1-CaMapo (Upper Left), KCNQ1-CaMML277 (Upper Right), KCNQ1-CaMML277-PIP2-A (Lower Left), and KCNQ1-CaMML277-PIP2-B (Lower Right). KCNQ1, ML227, PIP2, and CaM are labeled. (B) Pore radii along the ion permeation pathway in different KCNQ1-CaM structures. Key residues forming the two constriction layers of the activation gate in the closed KCNQ1 are labeled.
