Table 1.
Summary of patient characteristics
| Total | FTD-MND | bvFTD | nfvFTD | svFTD | phFTD | Slowly progressive bvFTD | Normal pressure hydrocephalus (FTD mimic) | |
| Number | 50 | 4 | 20 | 9 | 11 | 2 | 3 | 1 |
| Mean age (SD), y | 67.2 (8.4) | 68.5 (16.2) | 65.5 (9.2) | 68.4 (6.7) | 68.4 (6.0) | 71.5 (6.36) | 67.7 (8.5) | 61 |
| Mean age onset (SD), y | 62.3 (8.4) | 66.0 (15.3) | 61.1 (8.8) | 64.7 (7.6) | 62.3 (5.8) | 62.5 (4.95) | 58.3 (10.0) | 55 |
| Male % | 68 | 50 | 81 | 66.7 | 45.5 | 50 | 100 | 100 |
| Disease duration, mean (SD), y | 5.0 (2.8) | 2.8 (1.3) | 4.2 (1.8) | 3.8 (2.4) | 6.1 (2.9) | 9.0 (1.4) | 9.7 (1.2) | 6 |
| Serum NfL, median (IQR), pg/mL | 79.67 (45.32) | 41.10 (50.72) | 42.61 (22.93) | 44.38 (16.61) | 13.99 (0.79) | 17.97 (3.62) | 30.8 | |
| Duration of follow-up, mean (SD), y | 3.6 (2.4) | 3.3 (1.7) | 4.4 (2.1) | 3.6 (1.3) | 4.2 (2.1) | 3.0 (2.8) | 9 (3.0) | 8 |
| CBI | NA | 85.8 (12.8) | 24.3 (14.7) | 26.3 (10.1) | 64 | NA | 72 | |
| CBI number | NA | 5 | 7 | 3 | 1 | NA | 1 | |
| ACE-R | NA | 71.0 (21.9) | 82.0 (7.6) | 70.4 (16.2) | 84 | 83 | 90 | |
| ACE-R number | NA | 12 | 4 | 7 | 1 | 1 | 1 | |
| MMSE | NA | 25.1 (3.7) | 28.0 (1.6) | 26.1 (3.2) | 27.0 (2.8) | 24.0 (1.4) | 28 | |
| MMSE number | NA | 19 | 6 | 8 | 2 | 2 | 1 |
SD, standard deviation; NfL, neurofilament light; IQR, interquartile range; CBI, Cambridge Behavioural Inventory; ACE-R, Addenbrooke’s Cognitive Examination-Revised; MMSE, Mini-Mental State Examination; FTD-MND, frontotemporal dementia with motor neuron disease; bvFTD, behavioral variant frontotemporal dementia; phFTD, frontotemporal dementia phenocopy; nfvFTD, non-fluent variant frontotemporal dementia; svFTD, semantic variant frontotemporal dementia.