Table 2.
Neuropathologic findings stratified by dementia presence
| Variable | No Dementia n = 72 | Dementia n = 89 | p |
| Brain weight, g | 1200 (1120,1280) | 1115 (1040,1215) | <0.001 |
| Braak stage | IV (II,IV) | V (IV,V) | <0.001 |
| Neuritic plaque score | <0.001 | ||
| None, % | 25/72 (35%) | 6/89 (7%) | |
| Sparse, % | 11/72 (15%) | 13/89 (15%) | |
| Moderate, % | 21/72 (29%) | 37/89 (42%) | |
| Frequent, % | 15/72 (21%) | 33/89 (37%) | |
| Diffuse plaque score | <0.001 | ||
| None, % | 13/64 (20%) | 1/85 (1%) | |
| Sparse, % | 8/64 (13%) | 5/85 (6%) | |
| Moderate, % | 14/64 (22%) | 18/85 (21%) | |
| Frequent, % | 29/64 (45%) | 61/85 (72%) | |
| Lewy body pathology | 0.73 | ||
| None, % | 55/72 (76%) | 65/89 (73%) | |
| Lewy body disease, % | 12/72 (17%) | 19/89 (21%) | |
| Amygdala predominant Lewy bodies, % | 5/72 (7%) | 5/89 (6%) | |
| LATE-NC in amygdala | <0.001 | ||
| TDP-43 negative, % | 25/54 (46%) | 14/63 (22%) | |
| Rare, % | 7/54 (13%) | 1/63 (2%) | |
| TDP-43 positive, % | 22/54 (41%) | 48/63 (76%) | |
| Cerebrovascular disease scales | |||
| Kalaria score | 4 (3, 7) | 5 (3, 7) | 0.71 |
| Strozyk score | 2 (1, 2) | 2 (1, 3) | 0.51 |
| Dickson score | 1 (0, 2) | 1 (0, 2) | 0.69 |
| Arteriolosclerosis severity | 2 (2, 3) | 2 (2, 3) | 0.748 |
Data are presented as median (25th percentile, 75th percentile) or proportion. Kruskal-Wallis rank sum test for numerical and ordered variables, Pearson’s Chi-squared test for categorical variables. g, grams; TDP-43, TAR DNA-binding protein of 43 kDa; LATE-NC, Limbic predominant age-related TDP-43 neuropathologic change in amygdala.