Table 3.
Neuropathologic findings stratified according to history of cancer, diabetes mellitus and coronary artery disease
| Variable | No Cancer n = 93 | Cancer n = 68 | p | No Diabetes Mellitus n = 149 | Diabetes mellitus n = 12 | p | No Coronary Disease Arteryn = 107 | Coronary Artery Diseasen = 54 | p |
| Brain weight, g | 1120 (1040,1200) | 1210 (1100,1300) | 0.002 | 1140 (1060,1260) | 1174 (1021,1260) | 0.88 | 1140 (1052,1278) | 1140 (1100,1235) | 0.70 |
| Braak stage | IV (IV,V) | IV (III,V) | 0.01 | IV (III,V) | V (IV,V) | 0.11 | IV (III,V) | IV (III,V) | 0.22 |
| Neuritic plaques | 0.80 | 0.81 | 0.03 | ||||||
| None,% | 16 (17%) | 15 (22%) | 29 (19%) | 2 (17%) | 17 (16%) | 14 (26%) | |||
| Sparse,% | 17 (18%) | 7 (10%) | 22 (15%) | 2 (17%) | 16 (15%) | 8 (15%) | |||
| Moderate,% | 31 (33%) | 27 (40%) | 54 (36%) | 4 (33%) | 36 (34%) | 22 (41%) | |||
| Frequent,% | 29 (31%) | 19 (28%) | 44 (30%) | 4 (33%) | 38 (35%) | 10 (18%) | |||
| Diffuse plaques | 0.25 | 0.24 | 0.01 | ||||||
| None,% | 9 (10%) | 5 (8.3%) | 14 (10%) | 0 (0.0%) | 5 (5%) | 9 (17%) | |||
| Sparse,% | 4 (4.5%) | 9 (15.0%) | 12 (9.0%) | 1 (8.0%) | 9 (9%) | 4 (8%) | |||
| Moderate,% | 19 (21%) | 13 (22%) | 30 (22%) | 2 (17%) | 17 (18%) | 15 (29%) | |||
| Frequent,% | 57 (64%) | 33 (55%) | 81 (59%) | 9 (75%) | 66 (68%) | 24 (46%) | |||
| Lewy body | 0.50 | 0.21 | 0.57 | ||||||
| None,% | 71 (76%) | 49 (72%) | 111 (74%) | 9 (75%) | 78 (73%) | 42 (78%) | |||
| LBD,% | 18 (19%) | 13 (19%) | 30 (20%) | 1 (8%) | 23 (21%) | 8 (15%) | |||
| ALB,% | 4 (4.3%) | 6 (8.8%) | 8 (5%) | 2 (17%) | 6 (6%) | 4 (7%) | |||
| LATE-NC | 0.10 | >0.99 | 0.08 | ||||||
| Negative,% | 20 (29%) | 19 (40%) | 36 (33%) | 3 (38%) | 24 (30%) | 15 (41%) | |||
| Rare,% | 3 (4%) | 5 (10%) | 8 (7.0%) | 0 (0.0%) | 3 (4%) | 5 (14%) | |||
| Positive,% | 46 (67%) | 24 (50%) | 65 (60%) | 5 (62%) | 53 (66%) | 17 (46%) | |||
| Cerebrovascular | |||||||||
| Kalaria score | 5 (3, 7) | 4 (3, 6) | 0.11 | 5 (3, 7) | 6 (3, 8) | 0.26 | 4 (3, 7) | 5 (3, 7) | 0.31 |
| Strozyk score | 2 (1, 3) | 2 (1, 2) | 0.08 | 2 (1, 3) | 3 (2, 3) | 0.12 | 2 (1, 3) | 2 (1, 3) | 0.16 |
| Dickson score | 1 (0, 3) | 0 (0, 2) | 0.009 | 1 (0, 2) | 2 (1, 3) | 0.05 | 1 (0, 2) | 1 (0, 2) | 0.05 |
| Arteriolosclerosis | 2 (2, 3) | 2 (2, 3) | 0.685 | 2 (2, 3) | 2 (2, 3) | 0.376 | 2 (2, 3) | 2 (2, 3) | 0.427 |
Data are presented as median (25th percentile, 75th percentile) using Kruskal-Wallis rank sum test or proportion using Pearson’s Chi-squared test. g, grams; LBD, Lewy body disease; ALB, Amygdala predominant Lewy bodies; LATE-NC, Limbic predominant age-related TDP-43 neuropathologic change in amygdala.