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. 2022 Oct 25;90(1):363–380. doi: 10.3233/JAD-220318

Fig. 4.

Fig. 4

Association between combined biomarkers. Associations between the combined biomarkers were assessed using Spearman’s correlation. A) NfL in serum and NPTX2 in CSF showed a weak negative correlation in the whole cohort. B) When stratified for diagnoses, serum and CSF NfL did not correlate in any of the diagnostic groups. C) GFAP in serum and NPTX2 in CSF showed a weak negative correlation in the whole cohort. D) When stratified for diagnoses, GFAP in serum and NPTX2 in CSF correlated positively in PDD/DLB, while no significant correlation was found in OND, FTD, and MCI-AD. E) A significant positive correlation was found for serum GFAP and serum NfL. F) When stratified for diagnoses, a significant positive correlation was found for serum GFAP and serum NfL in OND, FTD, MCI-AD, PDD/DLB. Lines represent linear regression and grey areas represent 95% confidence intervals. CSF, Cerebrospinal fluid; GFAP, Glial fibrillary acidic protein; NPTX2, Neuronal pentraxin-2; NfL, Neurofilament light; OND, Other neurological diseases; FTD, Frontotemporal dementia, MCI-AD, Mild cognitive impairment due to Alzheimer’s disease; PDD/DLB, Lewy body dementias.