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. 2022 Oct 25;90(1):363–380. doi: 10.3233/JAD-220318

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© 2022 – The authors. Published by IOS Press

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 5 — Association between CSF and serum biomarkers. Associations between CSF and serum biomarkers were assessed using Spearman’s correlation. A) A significant strong correlation was found for CSF and serum NfL. B) CSF and serum GFAP correlated moderately in the whole cohort. C) NfL in serum and CSF correlated in all diagnostic groups. D) GFAP in serum and CSF correlated in PDD/DLB, and showed a positive trend in OND and MCI-AD. No correlation was observed in FTD. Lines represent linear regression and grey areas represent 95% confidence intervals. CSF, Cerebrospinal fluid; NfL, Neurofilament light; GFAP, Glial fibrillary acidic protein; OND, Other neurological disease; FTD, Frontotemporal dementia; MCI-AD, Mild cognitive impairment due to Alzheimer’s disease; PDD/DLB, Lewy body dementias.