TABLE 2.
Comparison of immune responses developed during acute (week 8) and chronic (>week 16) infections by IL-5−/− and WT micea
| Infection and mice | IL-4 concn (U/ml)
|
IL-10 concn (U/ml)
|
IL-2 concn (U/ml)
|
IFN-γ concn (pg/ml)
|
TNF-α concn (pg/ml)
|
NO concn (μM)
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SEA | Anti-CD3 | SEA | Anti-CD3 | SEA | Anti-CD3 | SEA | Anti-CD3 | SEA | Anti-CD3 | SEA | Anti-CD3 | |
| Acute | ||||||||||||
| IL-5−/− | 36.2 ± 1.7 | 256 ± 19.4 | 38.6 ± 5.7 | 215 ± 32 | 0.85 ± 0.2 | 5 ± 0.9 | ND | 19.5 ± 1.8 | 106 ± 34 | 402 ± 130 | 5.2 ± 1.8 | 42.5 ± 8.3 |
| WT | 39.7 ± 15.2 | 235 ± 62 | 24.9 ± 4.8 | 244 ± 37 | 0.26 ± 0.3 | 3.1 ± 0.7 | ND | 18.3 ± 2.5 | 150 ± 46 | 358 ± 29 | 9.4 ± 1.7 | 32.1 ± 7.1 |
| Chronic | ||||||||||||
| IL-5−/− | 2.2 ± 0.5 | 54.2 ± 17 | 53.6 ± 6.3 | 254.4 ± 46 | 1.9 ± 0.1 | 3.1 ± 0.36 | ND | 75.8 ± 16.5 | 250 ± 29b | 673b ± 32 | 5.7 ± 1.8 | 25.2 ± 1.8 |
| WT | 0.53 ± 0.33 | 20.4 ± 5.5 | 28 ± 3.4 | 290.8 ± 34 | 1.0 ± 0.56 | 2.1 ± 0.5 | ND | 47.6 ± 7.7 | 47.4 ± 24 | 370 ± 43 | 4.4 ± 1.8 | 19.4 ± 4 |
a
Results are means ± standard errors and are representative of at least three separate experiments. ND, not detected.
b
P < 0.05 compared with WT mice.