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. 2022 Nov 14;13:6910. doi: 10.1038/s41467-022-34718-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Histological evaluation of the lung tissue at several time points, following the MIL-101 NP injection. The tissue slices were stained with eosin and Perls Prussian blue. n = 3 mice. Scale bars = 50 µm. b Evaluation of the iron concentration in the main organs after the MIL-101 NP injection: lungs (blue), liver (green), spleen (orange), kidneys (red), heart (grey). n = 3 mice. c Representative confocal images of rhodamine 123 distribution in the lung tissue at several time points following the MIL-101 NP injection. n = 3 mice. Fluorescence excitation/emission, 488/515-575 nm. Scale bars = 250 µm. d Kinetics of the mean fluorescence intensity of the lung tissue. Data were fitted using the developed theoretical model (red line). Grey line marks the mean ± SD tissue autofluorescence level. n = 3 mice. In b, d data are presented as mean values ± SD.