Table 7. Profile of Bicycle Toxin Conjugate BT8009a.
| plasma
protein binding (%) |
in vitro
plasma stability (t1/2, h) |
mouse
pharmacokinetics 3 mg/kg, IV (bolus) |
||||||
|---|---|---|---|---|---|---|---|---|
| human Nectin-4 KD (SPR) | mouse | human | solubility phosphate buffer pH 7.4(mg/mL) | mouse | human | T1/2 (h) | Clp (mL/min/kg) | Vss (L/kg) |
| 2.50 | 88.2 | 79.3 | 0.8 | 4.4 | >57.8 | 1.0 | 3.5 | 0.25 |
a
Affinity was measured using SPR. The Geomean of KD value displayed is generated from n = 13. Full assay details, including the number of replicates and errors, are in the Supporting Information.