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. 2022 Oct 21;65(21):14655–14672. doi: 10.1021/acs.jmedchem.2c01175

Table 3. P-gp Interaction Activity of Compounds 5 and 14 in MDCK-MDR1, MDCK-MRP1, and MDCK-BCRP Cells Overexpressing P-gp, MRP1, and BCRP, Respectively.

  EC50 μMa
compounds MDR1 MRP1 BCRP
5 0.15 ± 0.02 NA NA
14 0.18 ± 0.03 NA NA
a

Values are the mean ± standard error of the mean (SEM) of two independent experiments, with samples in triplicate. NA, not active.