Table 3. P-gp Interaction Activity of Compounds 5 and 14 in MDCK-MDR1, MDCK-MRP1, and MDCK-BCRP Cells Overexpressing P-gp, MRP1, and BCRP, Respectively.
EC50 μMa |
|||
---|---|---|---|
compounds | MDR1 | MRP1 | BCRP |
5 | 0.15 ± 0.02 | NA | NA |
14 | 0.18 ± 0.03 | NA | NA |
Values are the mean ± standard error of the mean (SEM) of two independent experiments, with samples in triplicate. NA, not active.