Scheme 1. Synthesis of Fragment Analogues 12, 14, and 15.
Reagents and conditions: (a) S8, malono-nitrile, l-proline, DMF, BMIMCl, 12 h, 70 °C, 61%; (b) K2CO3, CH3I, DMF, 18 h, 50 °C, 35%; and (c) XPhos Pd G3, Cs2CO3, dioxane, 1 h, 80 °C, 48%.
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