Table 2. Exploration of Position 5′ of Benzonitrile-Substituted Pyrimidinediones for BCAT1 and BCAT2 Activities^a.

^aIC₅₀ values given are arithmetic mean values over at least two independent IC₅₀ determinations.

^bCompounds 1 and 10–17 are assumed to be racemates; for further information, see the Supporting Information.