. 2022 Oct 19;65(21):14366–14390. doi: 10.1021/acs.jmedchem.2c00441

Table 3. Exploration of Position 6 of Benzonitrile-Substituted Pyrimidinediones for BCAT1 Activity and Intestinal Caco-2 Permeability and Measured pK_a Values^a.

IC₅₀ values given are arithmetic mean values over at least two independent IC₅₀ determinations.

Compounds 12 and 18–28 are assumed to be racemates; for further information, see the Supporting Information. n.a.: data not available.

Table 3. Exploration of Position 6 of Benzonitrile-Substituted Pyrimidinediones for BCAT1 Activity and Intestinal Caco-2 Permeability and Measured pKa Valuesa.