. 2022 Oct 19;65(21):14366–14390. doi: 10.1021/acs.jmedchem.2c00441

Table 4. Exploration of Positions 1′ and 5′ of Benzonitrile-Substituted Pyrimidinediones for BCAT1 and BCAT2 Activities and Intestinal Caco-2 Permeability^a.

IC₅₀ values given are arithmetic mean values over at least two independent IC₅₀ determinations.

Compounds 1, 12, 15, and 29–34 are assumed to be racemates; for further information, see the Supporting Information. n.a.: data not available.

Table 4. Exploration of Positions 1′ and 5′ of Benzonitrile-Substituted Pyrimidinediones for BCAT1 and BCAT2 Activities and Intestinal Caco-2 Permeabilitya.