Table 7. Pharmacokinetic Properties of Compound 36a (BAY-069)^a.

BAY-069 (36a)
metabolic stability		CLblood[L/h/kg]	Fmax [%]
	human liver microsomes	0.11	92
	rat hepatocytes	1.8	56
Caco-2 permeability	PappA–B[nm/s]	PappB–A [nm/s]	efflux ratio
	252	122	0.48

species	CLblood[L/h/kg]	Vss[L/kg]	t1/2 [h] iv	AUCnorm[kg·h/L] iv	AUCnorm[kg h/L] po	F [%] po
rat	0.64	0.25	1.6	2.9	2.5	89

^aDoses applied to rats were 0.3 mg/kg i.v. and 0.6 mg/kg for p.o. administration.