Table 1.
CB NK cells genetically modified to express the B7H3 CAR maintain chemokine receptor expression
| B7H3 CAR-NK |
UT-NK |
|||||
|---|---|---|---|---|---|---|
| Mean | Median | SD | Mean | Median | SD | |
| CD181 (CXCR1) | 22.47 | 10.19 | 24.11 | 18.91 | 4.7 | 24.56 |
| CD182 (CXCR2) | 7.30 | 5.705 | 3.89 | 4.73 | 4.8 | 2.23 |
| CD183 (CXCR3) | 99.32 | 99.25 | 0.24 | 98.87 | 98.9 | 0.39 |
| CD184 (CXCR4) | 99.45 | 99.65 | 0.48 | 96.95 | 98.5 | 3.09 |
| CD186(CXCR6) | 20.52 | 18.15 | 8.41 | 23.73 | 20.7 | 12.00 |
| CD191 (CCR1) | 15.24 | 10.33 | 12.88 | 12.29 | 7.6 | 11.57 |
| CD192 (CCR2) | 12.93 | 8.68 | 9.08 | 9.65 | 8.6 | 3.81 |
| CD193(CCR3) | 76.53 | 84.3 | 19.65 | 52.73 | 42.9 | 29.12 |
| CD194 (CCR4) | 79.15 | 93.35 | 24.23 | 74.03 | 83.4 | 25.86 |
| CD195 (CCR5) | 86.63 | 91.8 | 11.24 | 80.57 | 84.3 | 17.99 |
| CD196 (CCR6) | 34.05 | 18.45 | 38.29 | 27.77 | 10.3 | 34.29 |
| CD197 (CCR7) | 83.32 | 97.95 | 24.26 | 75.57 | 95.9 | 32.56 |
| CD198 (CCR8) | 62.98 | 63.95 | 27.12 | 59.00 | 46.9 | 26.70 |
| CD199 (CCR9) | 23.75 | 26 | 10.19 | 13.56 | 12.6 | 5.17 |
| CCR10 | 99.10 | 99.75 | 1.58 | 97.47 | 99.6 | 3.48 |
| CCX-CCR (CCRL1) | 72.62 | 63.8 | 17.13 | 64.63 | 53.4 | 24.08 |
| CXCR5 | 79.87 | 89.65 | 17.50 | 62.20 | 72.6 | 25.54 |
| CXCR7 | 62.73 | 64.1 | 27.65 | 59.98 | 50.7 | 24.99 |
| XCR1 | 19.83 | 17.1 | 17.36 | 19.66 | 24.6 | 14.08 |
Data shown as percentage (%) mean, median, and standard deviation (S.D) of receptors expression (n = 6).