Table 3.
Risk factors for thrombocytopenic events <50 × 109/L using multiple Cox proportional hazards models.a
| HCV (n = 1603) | HBV (n = 1504) | |||||
|---|---|---|---|---|---|---|
| Platelet events | 14 | 7 | ||||
| Follow-up (year) | 3054.06 | 8587.05 | ||||
| Incidence (per 100,000 person-years) |
458.41 |
81.52 |
||||
| Characteristic | AHR | 95% CI | p | AHR | 95% CI | p |
| Initial platelet level | ||||||
| 1 or 2 (≥100 × 109/L) | 1.00 | 1.000 | ||||
| 3 (50–99 × 109/L) | 13.24 | 2.99–58.59 | <0.001 | 50.42 | 7.69–330.30 | <0.001 |
| ALP —U/L | ||||||
| ≥200 | 7.92 | 1.57–40.01 | <0.001 | 5.27 | 1.34–20.76 | 0.015 |
| <200 | 1.00 | 1.00 | ||||
| Total bilirubin —mg/dL | ||||||
| ≥2.0 | 5.47 | 1.12–26.68 | 0.032 | |||
| <2.0 | 1.00 | |||||
| PT prolongation —second | ||||||
| ≥4.0 | 5.85 | 1.36–25.13 | 0.015 | |||
| <4.0 | 1.00 | |||||
Abbreviations: HCV: hepatitis C virus; HBV: hepatitis B virus; AHR: adjusted hazard ratio; ALP: alkaline phosphatase; PT: prothrombin time; CI: confidence interval.
a
Only the covariates with statistical significance in the multiple Cox model were presented.