Figure 5:

Specificity for cardiac hNa_V1.5 channels.

(A) Representative whole-cell currents according to the indicated pulse protocol before (black) and about 5 min after application of 1 µM hemin (color) for hNa_V1.5, hNa_V1.2, hNa_V1.4, hNa_V1.7, and hNa_V1.8c4. (B) Mean time course of peak currents at −30 mV, recorded at intervals of 4 s, for the different channel isoforms as indicated by the colors as in (A). (C) Statistics for the mean remaining current after 5 min exposure to 1 µM hemin. Data in (B) and (C) are mean ± sem with n in parentheses (C).