. 2022 Oct 31;13(11):1769–1775. doi: 10.1021/acsmedchemlett.2c00394

Table 1. Anti-HER2 Binder Name and Protein Scaffold Type^a.

Binder Name	K_D (nM)	PDB	Type
ZHER2	0.022	2KZI(solution)²⁹	Affibody
G3	0.9	2JAB(30)	DARPin
Pertuzumab	1.6	1S78/4LLW³¹	Fab
9.29	3.8	4HRL(30)	DARPin
73J	8.6	–³²	Fab
Trastuzumab	0.5	1N8Z(33)	Fab

Fusion of βN fragment or βC fragment at either the N- or C-terminus of each binder resulted in four constructs per binder. Each βN construct was tested with every βC construct, giving 169 pairs screened. Binding affinities are from references listed.

Table 1. Anti-HER2 Binder Name and Protein Scaffold Typea.

Table 1. Anti-HER2 Binder Name and Protein Scaffold Type^a.