Table 1. Antiaggregating Activities of Compounds 1–3 Compared with Corresponding Anodic Peaks (E_p) and Standard Redox Potentials (E_1/2).

	inhibition of Aβ42 self-aggregation
cpd	% inhibition by ThT [I] = 50 μMa (IC50 ± SEM/μM)	% inhibition by MS ± SD [I] = 50 μMb	Ep(ox) (V)	E1/2(ox)c (V)
1	>90 (3.99 ± 0.39)d	56.9 ± 3.5	0.19	0.10
2	<10	<10	0.76	0.66
3	>90 (10.2 ± 1.3)	43.6 ± 0.7	0.32	0.10

^aInhibition of Aβ₄₂ 50 μM self-aggregation by [I] = 50 μM (tested compound/Aβ₄₂ = 1/1). For compounds showing a % inhibition greater than 50%, the IC₅₀ value was determined. Values are the mean of two independent experiments each performed in duplicate. SEM = standard error of the mean.

^bStudies were performed by incubating Aβ₄₂ samples under the assay conditions used for the ThT assay, with and without tested compounds at 50 μM (tested compound/Aβ₄₂ = 1/1). Experiments were performed in duplicate. SD = standard deviation.

^cHalfwave (E_1/2) redox potential values estimated by digital simulation of the experimental voltammetric curves.

^dIC₅₀ already reported in ref (5).