Table 4. PK Parameters for Compounds 5f, 5g, and 6.

compound	routea	dose (mg/kg)	Cmax (nM)	AUC (nM·h)	%F	%HBF	Vss (L/kg)
5f	iv (r)	0.5				>100	3.2
5f	po (r)	3.0	752	666	92
5g	iv (r)	0.5				>100	1.1
5g	po (r)	3.0	992	1150	100
5g	iv (c)	0.5				70	3.5
5g	po (c)	2.0	138	739	100
6	iv (r)	0.5				96	2.0
6	po (r)	3.0	562	1134	59
6	iv (c)	0.3				48	1.2
6b	po (c)	2.0	56	388	12

^ar = rat, c = cyno.

^bAdjusted from 1 mg/kg dose for comparison.