Table A.1Common adverse events in the cohort group (n = 120)
| Events/Grade | Grade 1 |
Grade 2 |
Grade 3 |
Grade 4 |
Grade 3 or 4 |
|---|---|---|---|---|---|
| Number of patients | % | ||||
| Allergic reaction | 3 | 1 | 0 | 0 | 0 |
| Left ventricular systolic dysfunction | 3 | 2 | 1 | 0 | 0.8 |
| Left ventricular diastolic dysfunction | 2 | 1 | 1 | 1 | 0.8 |
| Hypertension | 14 | 3 | 1 | 0 | 0.8 |
| Fatigue | 13 | 6 | 3 | 0 | 2.5 |
| Nausea | 11 | 3 | 0 | 0 | 0 |
| Vomiting | 7 | 3 | 0 | 0 | 0 |
| Diarrhea | 8 | 2 | 0 | 0 | 0 |
| Anorexia | 16 | 2 | 3 | 0 | 2.5 |
| Oral cavity mucositis (clinical exam) | 8 | 2 | 0 | 0 | 0 |
| Alopecia | 6 | 16 | – | – | – |
| Nail changes | 16 | 3 | 0 | – | 0 |
| Fracture | 0 | 4 | 2 | 1 | 2.5 |
| Pain (muscle) | 5 | 4 | 2 | 0 | 1.7 |
| Fever | 3 | 3 | 0 | 0 | 0 |