Table 3. Mouse PK Profile of Compound 30.
| admin. | dose (mg/kg) | Tmax (h) | C0 (ng h) | Cmax (ng h) | AUC(0–t) (ng h/mL) | AUC(0–∞) (ng h/mL) | Cl (L h–1 kg–1) | t1/2 (h) | MRT (0–t) (h) | F (%) |
|---|---|---|---|---|---|---|---|---|---|---|
| iga | 20 | 0.25 | – | 4075 | 13379 | 13476 | – | 1.18 | 2.65 | 253.29 |
| ivb | 1 | – | 1075 | – | 264 | 264 | 3.78 | 0.20 | 0.26 | – |
Intragastric administration (oral gavage).
Intravenous injection.