Fig. 6.

Binding of Helicobacter pylori strain J99 wt to human gastric mucins isolated from Helicobacter spp.-infected (Inf) and -noninfected (Non-inf) individuals.A, the mean binding signal from the four mucin sources from each individual. B, the binding signal from mucins from the surface soluble mucin source from each individual. The other three mucins sources can be found in supplemental Fig. S2. Circles denote samples from secretors and squares from nonsecretors. White symbols denote samples in which none of the four mucin types bound statistically significantly better to J99 wt than wells with no mucins from the same microwell plate, and black symbols denote samples that bound J99 wt. The bars represent mean ± SEM, ∗p < 0.05 and ∗∗p < 0.01; A and B: Student’s t test. C, LC–MS chromatograms of O-glycans from the surface soluble mucin sample within each group with the highest avidity for H. pylori J99 wt.