Table 3.
Patient characteristics, gastritis, and Helicobacter spp. status for the patients from whom mucins were isolated from (A) and for the patients from whom O-glycans were characterized from (B)
| A | Helicobacter spp. negative (n = 36) | Helicobacter spp. positive (n = 17) |
|---|---|---|
| Female (%/number) | 83%/n = 30 | 88%/n = 15 |
| Age (mean/median/range) | 41.9/43.0/24–60 | 43.8/45.0/28–59 |
| Body mass index (kg/m2,, mean/median/range) | 40.64/40.20/34.00–53.50 | 38.72/38.10/34.80–46.10 |
| Healthy (apart from obesity, %/number) | 28%/n = 10 | 41%/n = 7 |
| Diabetes (type 1 or 2, %/number) | 11%/n = 4 | 6%/n = 1 |
| Proton pump inhibitor treatment (%/number) | 8%/n = 3 | 12%/n = 2 |
| Gastritis (histology score 0–5, mean/median/interquartile range) | 1.25/0.50/2.25 | 2.77/3.00/3.00a |
| Lea+ (%/number) | 47/%/n = 7 | 71%/n = 12 |
| Leb+ (%/number) | 42%/n = 15 | 41%/n = 7 |
| Lea+/Leb+ (%/number) | 11%/n = 4 | 12%/n = 2 |
| Lea+/Leb− (%/number) | 36%/n = 13 | 59%/n = 10 |
| Lea−/Leb+ (%/number) | 31%/n = 11 | 29%/n = 5 |
| Lea−/Leb− (%/number) | 22%/n = 8 | 0%/n = 0 |
| Blood group O (%/number) | 22%/n = 8 | 35%/n = 6 |
| Blood group A (%/number) | 64%/n = 23 | 35%/n = 6 |
| Blood group B (%/number) | 11%/n = 4 | 17%/n = 3 |
| Blood group AB (%/number) | 3%/n = 1 | 12%/n = 2 |
| B | Helicobacter spp. negative (14 individuals/53 samples) | Helicobacter spp. positive (14 individuals/52 samples) |
|---|---|---|
| Female (%/number) | 79%/n = 11 | 86%/n = 12 |
| Age (mean/median/range) | 45.9/48.0/28–57 | 43.1/43.5/28–59 |
| Body mass index (kg/m2) (mean/range) | 41.25/40.35/37.30–49.90 | 38.48/38.20/34.80–45.00 |
| Healthy (apart from obesity, %/number) | 36%/n = 5 | 36%/n = 5 |
| Diabetes (type 1 or 2, %/number) | 14%/n = 2 | 7%/n = 1 |
| Protom pump inhibitor treatment (%/number) | 7%/n = 1 | 14%/n = 2 |
| Gastritis (histology score 0–5, mean/median/interquartile range) | 0.07/0.00/0.00a | 3.14/3.00/1.00a |
| Lea+ (%/number) | 50%/n = 7 | 43%/n = 6 |
| Leb+ (%/number) | 50%/n = 7 | 64%/n = 9 |
| Lea+/Leb+ (%/number) | 14%/n = 2 | 7%/n = 1 |
| Lea+/Leb&minus (%/number) | 36%/n = 5 | 57%/n = 8 |
| Lea−/Leb+ (%/number) | 36%/n = 5 | 36%/n = 5 |
| Lea−/Leb− (%/number) | 14%/n = 2 | 0%/n = 0 |
| Blood group O (%/number) | 29%/n = 4 | 29%/n = 4 |
| Blood group A (%/number) | 57%/n = 8 | 36%/n = 5 |
| Blood group B (%/number) | 7%/n = 1 | 21%/n = 3 |
| Blood group AB (%/number) | 7%/n = 1 | 14%/n = 2 |
a
Refers to that the gastritis scores for samples positive for Helicobacter spp. were higher than from negative samples, Mann–Whitney U test, p < 0.05. Means and medians are presented together to nuance the data where applicable. ABO blood group was obtained from the patient charts, whereas Leb and Lea presence on mucins were analyzed by ELISA.