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. 2022 Nov 14;20:398. doi: 10.1186/s12916-022-02595-8

Fig. 4.

Fig. 4

Dynamic changes in CSF ctDNA concentration better predict intracranial tumor response than plasma. Kaplan-Meier curves of intracranial progression-free survival (A) and extracranial progression-free survival (B) between patients with and without CSF ctDNA response. Kaplan-Meier curves of intracranial progression-free survival (C) and extracranial progression-free survival (D) between patients with and without plasma ctDNA response. P-values were calculated using the log-rank test. Abbreviations: CSF, cerebrospinal fluid; ctDNA, circulating tumor DNA; HR, hazards ratio; PFS, progression-free survival