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. 2022 Nov 14;19:90. doi: 10.1186/s12987-022-00387-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Comparison between cortex & CSF/plasma concentration ratios of the two markers. Cortex/plasma (filled●) and CSF/plasma (open○) concentration ratios (%) of sucrose (A) and dextran (B) in E16, E19, P4 and adult rats. Samples collected 5 min following i.v. injection of ³H-dextran or ¹⁴C-sucrose. Note sucrose CSF ratios were higher than brain ratios in younger animals but dextran ratios were similar at all ages. Mean ± SD, some error bars are too small to be visible; n = 3–6