TABLE 2.
Colonization of C57Bl/6 and BALB/c mice by three H. pylori strains
| Mouse strain | H. pylori strain (no. of inocu-lated mice) | Wks post-inoculation | No. of mice positive for H. pylori/total no. of mice | Log CFU/ stomachb |
|---|---|---|---|---|
| C57Bl/6 | SS1 (16) | 5 | 8/8 | 4.17 ± 0.12 |
| 12 | 8/8 | NAa | ||
| SPM326/IL-8+ (16) | 5 | 7/8 | 2.64 ± 0.58† | |
| 12 | 2/8 | 1.32 ± 0.76* | ||
| SPM326/IL-8− (16) | 5 | 6/8 | 3.75 ± 0.18†‡ | |
| 12 | 2/8 | 3.71 ± 0.18‡ | ||
| BALB/c | SS1 (16) | 5 | 8/8 | 4.21 ± 0.17 |
| 12 | 8/8 | 3.98 ± 0.41 | ||
| SPM326/IL-8+ (16) | 5 | 0/8 | 0 | |
| 12 | 0/8 | 0 | ||
| SPM326/IL-8− (16) | 5 | 3/8 | 3.87 ± 0.03† | |
| 12 | 5/8 | 2.81 ± 0.14*† |
a
NA, not available. H. pylori was detected for eight of eight mice in Giemsa-stained sections.
b
†, P < 0.009, SS1 infection compared with SPM326/IL-8+ and SPM326/IL-8− at the same time point in the same mouse strain. ∗, P < 0.03, infection at 5 weeks compared with at 12 weeks; ‡, P ≤ 0.001, infection with SPM326/IL-8+ compared with SPM326/IL-8−.