Table 2.
CMR parameters and annualized change by composite outcome status
| Parameter | Overall (n = 156) | Composite outcome | p value | |
|---|---|---|---|---|
| Yes (n = 22) | No (n = 134) | |||
|
Follow-up time, years, Median (IQR) |
10.2 (6.1,14.5) | 6.2 (3.9, 8.4) | 10.8 (6.9, 15.3) | < 0.001 |
| Male | 100 (64.1%) | 14 (63.6%) | 86 (64.2%) | 0.96 |
| Ventricular dominance | 0.03 | |||
| Left ventricle | 83 (53.2%) | 7 (31.8%) | 76 (56.7%) | |
| Right ventricle | 73 (46.8%) | 15 (68.2%) | 58 (43.3%) | |
| At the first CMR | ||||
| Age at CMR, years | 17.8 ± 9.6 | 22.0 ± 13.5 | 17.1 ± 8.6 | 0.11 |
| BSA, m2 | 1.47 ± 0.41 | 1.57 ± 0.53 | 1.46 ± 0.39 | 0.34 |
| EDVI, ml/BSA1.3 | 98.3 ± 37.5 | 120.9 ± 58.3 | 94.6 ± 31.7 | 0.05 |
| ESVI, ml/BSA1.3 | 47.7 ± 26.8 | 63.9 ± 43.8 | 45.0 ± 22.0 | 0.06 |
| Mass index, g/BSA1.3 | 62.0 ± 23.1 | 80.6 ± 32.5 | 58.8 ± 19.6 | 0.005 |
| EF, % | 53.3 ± 10.0 | 49.5 ± 12.4 | 54.0 ± 9.5 | 0.05 |
| Mass-to-volume ratio | 0.69 ± 0.31 | 0.79 ± 0.43 | 0.67 ± 0.29 | 0.23 |
| ESWS, kPa | 17.7 ± 6.7 | 20.5 ± 7.5 | 17.4 ± 6.6 | 0.17 |
| At the last CMR | n = 155b | n = 21 | n = 134 | |
| Age at CMR, years | 23.7 ± 10.6 | 26.7 ± 14.5 | 23.3 ± 9.9 | 0.30 |
| Time between 2 CMRs, Median (IQR) | 5.0 (2.3, 8.7) | 4.4 (2.0, 5.9) | 5.1 (2.3, 9.0) | 0.04 |
| BSA, m2 | 1.69 ± 0.37 | 1.72 ± 0.46 | 1.68 ± 0.36 | 0.71 |
| EDVI, ml/BSA1.3 | 106.3 ± 39.5 | 146.3 ± 69.9 | 100.0 ± 28.0 | 0.007 |
| ESVI, ml/BSA1.3 | 54.8 ± 34.5 | 88.7 ± 68.3 | 49.5 ± 21.6 | 0.02 |
| Mass indx, g/BSA1.3 | 54.2 ± 18.0 | 73.5 ± 26.5 | 51.2 ± 14.2 | 0.001 |
| EF, % | 50.9 ± 9.9 | 43.8 ± 13.8 | 52.0 ± 8.7 | 0.01 |
| Mass-to-volume ratio | 0.54 ± 0.16 | 0.56 ± 0.24 | 0.53 ± 0.14 | 0.58 |
| ESWS, kPa | 18.8 ± 7.8 | 22.4 ± 10.9 | 18.3 ± 7.1 | 0.11 |
| Annual change in CMR (last-first)/(years between last and first) | ||||
|
EDVI, ml/BSA1.3/year, Median (IQR) |
0.93 (− 0.97, 3.20)a | 4.68 (1.11, 8.79)a | 0.70 (− 1.40, 2.64)a | 0.003 |
|
ESVI, ml/BSA1.3/year, Median (IQR) |
0.84 (− 0.72, 2.51)a | 3.62 (0.91, 9.60)a | 0.70 (− 0.76, 1.99)a | < 0.001 |
|
Mass index, g/BSA1.3/year, Median (IQR) |
− 1.06 (− 3.12, 0.71)a | − 4.49 (− 5.30, 0.36) | − 0.92 (− 2.21, 0.71)a | 0.04 |
|
EF, %/year, Median (IQR) |
− 0.35 (− 1.25, 0.41)a | − 0.99 (− 5.12, 0.29)a | − 0.30 (− 1.17, 0.41)a | 0.03 |
|
Mass-to-volume ratio, /year, Median (IQR) |
− 0.02 (− 0.05, 0.01)a | − 0.06 (− 0.10, − 0.03)a | − 0.01 (− 0.04, 0.01)a | 0.006 |
|
ESWS, kPa/year, Median (IQR) |
0.30 (− 0.59, 1.23) | 3.12 (1.55, 4.97)a | 0.17 (− 0.73, 0.81) | 0.002 |
Bold indicates p-value < 0.05
aIndicates that the change is significantly different from 0
bOne patient had transplant listing prior to their last CMR BSA, body surface area; CMR, cardiovascular magnetic resonance; LV, left ventricle; RV, right ventricle/right ventricular