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. 2022 Sep 8;9(32):2204067. doi: 10.1002/advs.202204067

Figure 2.

Figure 2

Enhanced transcytosis of PRNs at pH 6.7. A) Schematic showing recycling endosomes transport of intracellular cargos to extracellular space. B) Confocal images showing co‐localization of rab11+ recycling endosomes (green) and PRNs (red) at pH 6.7. C) Calculation of the co‐localization index of rab 11+ recycling endosomes and PRNs. D,E) Schematic illustration of real‐time monitor and confocal images of active transcytosis of PRNs at pH 6.7. F,G) Time‐dependent MFI changes of PRNs/Cy5 in adhered cells (F) and suspending cells (G) (n = 3). H) MFI calculation of the added suspending cells after 60 min incubation with adhered cells (n = 12). I) Schematic showing that transcellular transport of PRNsMT from adhered cells to suspending cells. Data are shown as mean ± SD by one‐way analysis of variance (ANOVA) was used. **p < 0.005, ***p < 0.001, ****p < 0.0001.