Table 3.
Univariable and multivariate analysis on plasma PGAM5 and oligomeric α-sync levels and other clinical characteristics in logistic regression.
| Variables | Univariable analysis | Multivariable analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| β | Wald χ2 | p-value | OR (95% CI) | β | Wald χ2 | p-value | OR (95% CI) | |
| Age | −0.05 | 0.09 | 0.76 | 0.95 (0.70–1.30) | ||||
| Sex | 0.44 | 1.45 | 0.23 | 1.55 (0.76–3.14) | ||||
| BMI | 0.03 | 0.54 | 0.46 | 1.03 (0.95–1.13) | ||||
| HTN | −0.85 | 5.46 | 0.02 | 0.43 (0.21–0.87) | −0.93 | 3.60 | 0.058 | 0.40 (0.15–1.03) |
| DM | 2.34 | 5.01 | 0.03 | 10.35 (1.34–80.08) | 3.16 | 7.01 | 0.008 | 23.67 (2.28–246.33) |
| Cognitive impairment | 0.72 | 2.58 | 0.11 | 2.05 (0.85–4.92) | ||||
| Depression | 0.91 | 0.67 | 0.42 | 2.47 (0.28–21.79) | ||||
| Anxiety | 2.34 | 9.64 | 0.002 | 10.41 (2.37–45.69) | 2.36 | 7.94 | 0.005 | 10.61 (2.05–54.82) |
| RBD | 2.21 | 18.45 | 0.0001 | 9.12 (3.33–24.99) | 1.23 | 4.27 | 0.039 | 3.43 (1.07–11.04) |
| PGAM5 | 0.85 | 19.93 | 0.0001 | 2.34 (1.61–3.40) | 0.63 | 7.79 | 0.005 | 1.88 (1.21–2.92) |
| Oligomeric α-syn | 0.59 | 11.41 | 0.001 | 1.798 (1.28–2.53) | 0.51 | 5.15 | 0.023 | 1.67 (1.07–2.60) |
The cutoff point of the MMSE for cognitive impairment was adjusted according to years of education. Patients who were illiterate according to the level ≤17 points, and a primary school education according to the level ≤20 points, postsecondary education or above according to the level ≤24 points; Hamilton Depression Rating Scale (HAMD) and the Hamilton Anxiety Rating Scale (HAMA) for emotion examination; depression was defined when HAMD score ≥17 points; and anxiety was defined as a HAMA score ≥14 points. The RBDQ-HK rating scale was used to detect whether subjects with a REM sleep behavior disorder (RBD) were defined when the RBDQ-HK score was ≥18 points. BMI, body mass index; plasma levels of PAMG5 and oligomeric α-syn were both graded in quartiles (grade 1–4).